Or you can find my Google Scholar.
2022
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Testing Results from Pathfinder HgCdTe Infrared Detectors for the Near-Earth Object Surveyor Mission
Nick S. Reilly , Gregory Zengilowski , Sean Carey , and 15 more authors
In X-Ray, Optical, and Infrared Detectors for Astronomy X , Aug 2022
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/12191/2629687/Testing-results-from-pathfinder-HgCdTe-infrared-detectors-for-the-Near/10.1117/12.2629687.full
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Modulation Transfer Function Measurements of HgCdTe Long Wavelength Infrared Arrays for the Near-Earth Object Surveyor
Gregory R. Zengilowski , Craig W. McMurtry , Judith L. Pipher , and 7 more authors
Journal of Astronomical Telescopes, Instruments, and Systems, Jan 2022
2021
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Blooming in H2RG Arrays: Laboratory Measurements of a Second Brighter-Fatter Type Effect in HgCdTe Infrared Detectors
Gregory R. Zengilowski , Mario S. Cabrera , Craig W. McMurtry , and 7 more authors
Journal of Astronomical Telescopes, Instruments, and Systems, Jun 2021
\urlhttps://www.spiedigitallibrary.org/journals/Journal-of-Astronomical-Telescopes-Instruments-and-Systems/volume-7/issue-02/026002/Blooming-in-H2RG-arrays–laboratory-measurements-of-a-second/10.1117/1.JATIS.7.2.026002.full
2020
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CD4+ T Cell Interstitial Migration Controlled by Fibronectin in the Inflamed Skin
Ninoshka R. J. Fernandes , Nicholas S. Reilly , Dillon C. Schrock , and 3 more authors
Frontiers in Immunology, Jul 2020
\urlhttps://www.frontiersin.org/article/10.3389/fimmu.2020.01501/full
The extracellular matrix (ECM) is extensively remodeled during inflammation providing essential guidance cues for immune cell migration and signals for cell activation and survival. There is increasing interest in the therapeutic targeting of ECM to mitigate chronic inflammatory diseases and enhance access to the tumor microenvironment. T cells utilize the ECM as a scaffold for interstitial migration, dependent on T cell expression of matrix-binding integrins αVβ1/αVβ3 and tissue display of the respective RGD-containing ligands. The specific ECM components that control T cell migration are unclear. Fibronectin (FN), a canonical RGD-containing matrix component, is heavily upregulated in inflamed tissues and in vitro can serve as a substrate for leukocyte migration. However, limited by lack of tools to intravitally visualize and manipulate FN, the specific role of FN in effector T cell migration in vivo is unknown. Here, we utilize fluorescently-tagged FN to probe for FN deposition, and intravital multiphoton microscopy to visualize T cell migration relative to FN in the inflamed ear dermis. Th1 cells were found to migrate along FN fibers, with T cells appearing to actively push or pull against flexible FN fibers. To determine the importance of T cell interactions with FN, we used a specific inhibitor of FN polymerization, pUR4. Intradermal delivery of pUR4 (but not the control peptide) to the inflamed skin resulted in a local reduction in FN deposition. We also saw a striking attenuation of Th1 effector T cell movement at the pUR4 injection site, suggesting FN plays a key role in T cell interstitial migration. In mechanistic studies, pUR4 incubation with FN in vitro resulted in enhanced tethering of T cells to FN matrix, limiting productive migration. In vivo, such tethering led to increased Th1 accumulation in the inflamed dermis. Enhanced Th1 accumulation exacerbated inflammation with increased Th1 activation and IFNγ cytokine production. Thus, our studies highlight the importance of ECM FN fibrils for T cell migration in inflamed tissues and suggest that manipulating local levels of ECM FN may prove beneficial in promoting T cell accumulation in tissues and enhancing local immunity to infection or cancer.
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Cytokinetic Bridge Triggers de Novo Lumen Formation in Vivo
L. I. Rathbun , E. G. Colicino , J. Manikas , and 11 more authors
Nature Communications, Mar 2020
\urlhttp://www.nature.com/articles/s41467-020-15002-8
Abstract Multicellular rosettes are transient epithelial structures that serve as intermediates during diverse organ formation. We have identified a unique contributor to rosette formation in zebrafish Kupffer’s vesicle (KV) that requires cell division, specifically the final stage of mitosis termed abscission. KV utilizes a rosette as a prerequisite before forming a lumen surrounded by ciliated epithelial cells. Our studies identify that KV-destined cells remain interconnected by cytokinetic bridges that position at the rosette’s center. These bridges act as a landmark for directed Rab11 vesicle motility to deliver an essential cargo for lumen formation, CFTR (cystic fibrosis transmembrane conductance regulator). Here we report that premature bridge cleavage through laser ablation or inhibiting abscission using optogenetic clustering of Rab11 result in disrupted lumen formation. We present a model in which KV mitotic cells strategically place their cytokinetic bridges at the rosette center, where Rab11-associated vesicles transport CFTR to aid in lumen establishment.
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T\textsubscriptRMintegrins CD103 and CD49a Differentially Support Adherence and Motility after Resolution of Influenza Virus Infection
Emma C. Reilly , Kris Lambert Emo , Patrick M. Buckley , and 6 more authors
Proceedings of the National Academy of Sciences, May 2020
\urlhttp://www.pnas.org/lookup/doi/10.1073/pnas.1915681117
Tissue-resident memory CD8 T (TRM) cells are a unique immune memory subset that develops and remains in peripheral tissues at the site of infection, providing future host resistance upon reexposure to that pathogen. In the pulmonary system, T RM are identified through S1P antagonist CD69 and expression of integrins CD103/β7 and CD49a/CD29(β1). Contrary to the established role of CD69 on CD8 T cells, the functions of CD103 and CD49a on this population are not well defined. This study examines the expression patterns and functions of CD103 and CD49a with a specific focus on their impact on T cell motility during influenza virus infection. We show that the T RM cell surface phenotype develops by 2 wk postinfection, with the majority of the population expressing CD49a and a subset that is also positive for CD103. Despite a previously established role in retaining T RM in peripheral tissues, CD49a facilitates locomotion of virus-specific CD8 T cells, both in vitro and in vivo. These results demonstrate that CD49a may contribute to local surveillance mechanisms of the T RM population.
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Signal Nonlinearity Measurements and Corrections in MWIR and LWIR HgCdTe H2RG Arrays for NEO Surveyor
Greg Zengilowski , Craig W. McMurtry , Judith L. Pipher , and 6 more authors
In X-Ray, Optical, and Infrared Detectors for Astronomy IX , Dec 2020
\urlhttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/11454/2563138/Signal-nonlinearity-measurements-and-corrections-in-MWIR-and-LWIR-HgCdTe/10.1117/12.2563138.full
The depletion region around each p-n junction in HgCdTe HAWAII-2RG detector arrays decreases in volume as charge is collected, causing the pixel capacitance to change continuously throughout an integration period. This changing capacitance manifests as a steadily decreasing measured signal rate while observing a constant flux. Ignoring this nonlinear response to signal accumulation can lead to underestimating the number of detected photons by as much as 10%. Presented here are two methods, one simple and one complex, of measuring this signal nonlinearity and a theoretical framework behind a nonlinearity correction method. Additionally, experimental data are compared with simulations to explain methods to reduce noise in the nonlinearity measurement and identify deviations from the expected behavior that merit further study.
2019
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2014
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Thickness-Controlled Synthesis of Colloidal PbS Nanosheets and Their Thickness-Dependent Energy Gaps
Ghadendra B. Bhandari , Kamal Subedi , Yufan He , and 6 more authors
Chemistry of Materials, Sep 2014
\urlhttps://pubs.acs.org/doi/10.1021/cm502524z
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Ultrasmall Colloidal PbS Quantum Dots
Nick Reilly, Michael Wehrung , Ryan Andrew O’Dell , and 1 more author
Materials Chemistry and Physics, Sep 2014
https://linkinghub.elsevier.com/retrieve/pii/S0254058414002685
Ultrasmall colloidal lead sulfide quantum dots can increase the open circuit voltages of quantum-dotbased solar cells because of their large energy gap. Their small size and visible or near infrared lightemitting property make them attractive to the applications of biological fluorescence labeling. Through a modified organometallic route, we can synthesize lead sulfide quantum dots as small as 1.6 nm in diameter. The low reaction temperature and the addition of a chloroalkane cosolvent decrease the reaction rate, making it possible to obtain the ultrasmall quantum dots.